Cannabinoids

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Top 3 Cannabinoids of All-TIme

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What Are Cannabinoids?

CANNABINOIDS are crucial chemical compounds that stem from cannabis plants, including marijuana and hemp plants. All cannabinoids are not naturally derived from plants, the ones that are, however, are called PHYTOCANNABINOIDS.

To date, researchers have identified 180 distinct cannabinoids, each purported to deliver unique effects to the user. Evidence increasingly suggests that cannabinoids hold recreational, medicinal, and therapeutic potential.

This segment of our blog probes the infamous and famous cannabinoids we all know and love (and a few I’m sure you’ve never heard of). We’ll cover the intricate hierarchy of phytocannabinoids within cannabis plants, and a lot of the man-made compounds as well that are available for purchase and consumption at the click of a button.

Let’s illuminate the science behind these exceptional botanical components, and the exciting details of the ENDOCANNABINOIDS within us.

Important Definitions

If you really want to understand these magical hemp and marijuana compounds, you should start right here! All phytocannabinoids (cannabinoids derived from hemp) start from one single compound, CBGA; The Mother Cannabinoid.

From her alone, almost 200 more have been identified.

Events, Actions, & Reactions That Create or Transform Cannabinoids:

Oxidation:
A chemical reaction in which a substance loses electrons, often resulting in the addition of oxygen to a molecule or the removal of hydrogen.

Oxidative Degradation:
The breakdown of organic compounds due to reactions with oxygen.

Isomerization:
A chemical process by which a compound is transformed into any of its isomeric forms, i.e., forms with the same molecular formula but different structural arrangements.

Metabolic Byproduct:
A secondary or incidental product resulting from the metabolism of a primary compound.

Synthase:
An enzyme that catalyzes the synthesis of a specific compound or compounds in biological systems.

Decarboxylation:
The process of applying heat to convert cannabinoids in their acid form to their active form. For instance, turning THCA into THC.

MISC Terms:

Entourage Effect:
The theory that all the compounds in cannabis work together, and when taken together, they produce a better effect than when taken alone.

Flavonoid:
A group of phytonutrients responsible for the vivid colors in fruits, vegetables, and flowers, also found in cannabis. Some have medicinal properties.

Anandamide:
Commonly referred to as “The Bliss Molecule,” anandamide is an endocannabinoid, also known as N-arachidonoylethanolamine (AEA), which plays a role in pain, depression, appetite, memory, and fertility.

Derivative:
A compound that originates from a parent compound by the replacement of one or more atoms or groups or by other types of chemical transformations.

Homolog:
In organic chemistry, homologs are compounds in a series that have the same general formula but differ by a constant unit, often CH₂.

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Quick Insights On Cannabinoids

Naturally-occurring, plant-derived cannabinoids, such as THC and CBD, are referred to as phytocannabinoids (‘phyto’ denotes ‘from plants’). These substances are gaining substantial recognition in the scientific community because they possess molecular structures that are strikingly similar to endocannabinoids (‘endo’ signifies ‘from within’).

Did you know you had an Endocannabinoid System?

Here are three great articles you should dive into to get your feet soakin’ wet with the amazing chemical compounds within Cannabis.

A photo taken in a library shows twin sisters who stand for CBD and THC. The CBD sister looks neat and focused, staring right at the camera, holding a book labeled 'CBD' in big white letters. The THC sister looks a little messy with red, shiny eyes, seeming happy but spaced out, holding a book that says 'THC' in white letters too. The picture shows how different CBD and THC can make you feel.

CBD Vs. THC: The Differences & Similarities

A realistic photograph that playfully reimagines a presidential debate stage where translucent CBD gummy bears stand behind their respective representatives as they debate in a satirical exchange on whether CBD is psychoactive or if CBD is non-psychoactive. Donald Trump is satirically representing the CBD gummy bears that claim that CBD, is indeed, a Psychoactive substance.

CBD Is Psychoactive: The Evidence-Based End of the Debate

A microscopic view of comparison images of different cannabinoids, phytocannabinoids, and endocannabinoids.

Endocannabinoids Vs Phytocannabinoids: What’s The Difference?

Naturally Occuring Phytocannabinoids

We invite you to select a cannabinoid from the list below to explore in-depth information about its unique impact on the human body, its function, capabilities, benefits, and its collaborative role in a phenomenon known as the ‘Entourage Effect

Acidic Forms (Precursors):

CBGA (Cannabigerolic Acid)
CBDA (Cannabidiolic Acid)
THCA (Tetrahydrocannabinolic Acid)
CBCA (Cannabichromenic Acid)
CBDVA (Cannabidivarinic Acid)
THCVA (Tetrahydrocannabivarinic Acid)
CBCVA (Cannabichromevarinic Acid)
CBGVA (Cannabigerovarinic Acid)

Neutral Cannabinoids:

CBG (Cannabigerol)
CBD (Cannabidiol)
THC (Tetrahydrocannabinol)
CBC (Cannabichromene)
CBL (Cannabicyclol)
CBDV (Cannabidivarin)
THCV (Tetrahydrocannabivarin)
CBCV (Cannabichromevarin)
CBGV (Cannabigerivarin)
CBN (Cannabinol)