POP QUIZ!
What are the three key parts that make up the Endocannabinoid System?
A) Anandamide, Lipid Proteins, Metabolic EnzymesB) Neurotransmitters, Synapses, Cannabinoids
C) Endocannabinoids, Cannabinoid Receptors, Metabolic Enzymes
D) Endocannabinoids, CB1 Receptors, CB2 Receptors
Correct Answer: C
|Endocannabinoids, Cannabinoid Receptors, and Metabolic Enzymes are the three pivotal components of the ECS. Endocannabinoids are molecules that bind to and activate cannabinoid receptors; they are akin to the keys that unlock the receptors' functions. Cannabinoid Receptors, primarily CB1 and CB2, are the locks into which endocannabinoids fit, initiating various biological responses. Metabolic Enzymes ensure the ECS maintains balance by breaking down endocannabinoids once they've fulfilled their role. Together, these components work synergistically to regulate and maintain the body’s homeostasis.
Today, you’ll learn about the three main components of the Endocannabinoid System; covering the following four points for each:
- The scientific definition
- A detailed and more comprehensive explanation
- The roles & responsibilities
- The main types
Backed by tremendous research for every discussion point, you will find a supporting research study for verification.
#1. Endocannabinoids:
- Scientific definition: Endocannabinoids are endogenous lipid-based retrograde neurotransmitters that bind to cannabinoid receptors [1].
- Comprehensive Explanation: Endocannabinoids are naturally occurring molecules produced by the body that activate the same receptors as the active components in cannabis (cannabinoids). They are part of a complex cell-signaling system known as the endocannabinoid system, which helps regulate various physiological processes [2].
Roles and responsibilities:
- Modulating neurotransmitter release [3]
- Regulating pain, inflammation, and immune responses [4]
- Influencing appetite, mood, and memory [5]
- Maintaining homeostasis in the body [6]
Two Main Endocannabinoids In The ECS
The two main endocannabinoids are:
- anandamide (AEA)
- 2-arachidonoylglycerol (2-AG) [7].
#2 Cannabinoid Receptors:
- Scientific definition: Cannabinoid receptors are G protein-coupled receptors that are activated by endocannabinoids and exogenous cannabinoids [8].
- Comprehensive Explanation: Cannabinoid receptors are cell membrane receptors that bind to endocannabinoids and cannabinoids, triggering various cellular responses. They are found throughout the body, particularly in the central and peripheral nervous systems, as well as in immune cells [9].
Two Main Cannabinoid Receptors In The ECS
The two main types of cannabinoid receptors are CB1 and CB2 receptors [14].
#3. Metabolic Enzymes:
- Scientific definition: Metabolic enzymes are proteins that catalyze the synthesis, transport, and degradation of endocannabinoids [15].
- Comprehensive definition: Metabolic enzymes are responsible for the production, movement, and breakdown of endocannabinoids within the endocannabinoid system. They help maintain the balance of endocannabinoids in the body and ensure that they are available when needed and removed when their function is complete [16].
Four Main Metabolic Enzymes In The ECS
The main metabolic enzymes involved in the ECS are:
Summary & Final Thoughts
These three components work together to form the endocannabinoid system, which plays a crucial role in maintaining homeostasis and regulating various physiological processes in the body [25].
References
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- Lu, H. C., & Mackie, K. (2016). An introduction to the endogenous cannabinoid system. Biological psychiatry, 79(7), 516-525. https://doi.org/10.1016/j.biopsych.2015.07.028
- Kano, M., Ohno-Shosaku, T., Hashimotodani, Y., Uchigashima, M., & Watanabe, M. (2009). Endocannabinoid-mediated control of synaptic transmission. Physiological reviews, 89(1), 309-380. https://doi.org/10.1152/physrev.00019.2008
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- Mechoulam, R., & Parker, L. A. (2013). The endocannabinoid system and the brain. Annual review of psychology, 64, 21-47. https://doi.org/10.1146/annurev-psych-113011-143739
- Di Marzo, V. (2018). New approaches and challenges to targeting the endocannabinoid system. Nature reviews Drug discovery, 17(9), 623-639. https://doi.org/10.1038/nrd.2018.115
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